However, no pharmacological investigation has been carried out till date. The solanum nigrum complex also known as solanum l is group of solanum species with general black nightshade characteristic. Plants are playing a vital role in hepatoprotective activity. It is usually impossible to tell from older sources if the plant under discussion would now be classified as s. The present study was performed to evaluate the hepatoprotective. In order to find in vitro antioxidant properties, s. Hepatoprotective activity of aqueousethanolic extract of solanum. Pdf hepatoprotective activity of solanum nigrum extracts on. This study was aimed at investigating the protective effect of aqueous extract of the leaves of solanum macrocarpon against ccl 4induced liver damage in rats.
Solanum nigrum confers protection against ccl4induced. Hepatotoxicity induced by carbon tetrachloride ccl4 is used as an experimental model to screen phytochemicals with liver protecting activity. Solanum nigrum causes 73 and 82% of death after 3 days activity tests ofsolanum nigrumstem and leaf extracts with respect to 1500 ppm concentration of extract, are presented in fig 1. Potent anticancer and antioxidant activities of active. The extract of solanum nigrum and cichorium intybus possess significant hepatoprotective activity in comparison to standard drug silymarin. Journal of veterinary medicine and animal health 3. Pdf hepatoprotective activity of solanum nigrum extracts.
Pdf liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Six groups of four animals each were used for the investigation. Pdf the study was conducted to evaluate the hepatoprotective activity of solanum nigrum and cichorium intybus. Hepatoprotective effect of solanum surattense leaf extract. Chemicobiological interactions 171 2008 283293 available online at. Study of hepatoprotective activity of solanum nigrum and. Solanum nigrum confers protection against ccl 4 induced. Solanum nigrum leaf is one of the most important greens in throughout the world. Hepatoprotective effect of darhald berberis aristata dc. In this study, the protective effects of water extract of sn sne. The ethanol extract showed remarkable hepatoprotective activity. Hepatoprotective effects of solanum nigrum linn extract against ccl 4iduced oxidative damage in rats huimei lina, hsienchun tsenga,b, chaujong wanga, jinjin linc, chiawen loa, fenpi choua. Antiproliferative effect of solanum nigrum on human. Hepatoprotective activity of solanum nigrum extracts on chemically.
Its in vivo hepatoprotective effect at 20 mgkg body weight was. Phytochemical studies indicated that fruits of this species have as good concentrations of various alkaloids, flavonoids, saponins, tannins, and glycosides as sufficient to. The height of the plant is 40cm cm and leaves are 48 cm long. The study was conducted to evaluate the hepatoprotective activity of solanum nigrum and cichorium intybus. The solanum species in this group can be taxonomically confused, moreso by intermediate forms and hybridization between the species 1.
The hepatoprotective effects of solanum nigrum water and methanolic extracts were studied in rats injected with 0. Pdf study of hepatoprotective activity of solanum nigrum and. There is therefore need for hepatoprotective agents. Antimicrobial, antioxidant properties, hepatoprotective effects and analysis of bioactive natural compounds. Many previous studies have been carried out to determine the hepatoprotective effect of different extracts of s. Thirty three male sprague dawlay rats were divided into 6 groups g1. Potent anticancer and antioxidant activities of active ingredients separated from solanum nigrum and cassia italica extracts ahmed m. Hepatoprotective activity of crude extract of solanum nigrum for evaluation of hepatoprotective activity of crude extract of solanum nigrum, animals were divided into seven groups with seven animals in each group. Screening of hepatoprotective effect of methanolic extract of solanum nigrum against paracetamol induced hepatotoxicity in rabbits. Solanum nigrum leaves and seeds had ash value of 10. Although clinical documentation is scare as far as hepatoprotective activity is concerned, but some traditional practitioners have reported favorable results. Ethnobotanical notes and phytopharmacologiques on solanum. Ripe berries and cooked leaves of edible strains are used as food in some locales, and plant parts are used as a traditional medicine. Larvicidal and antibacterial activities of different.
The present work is aimed to investigate the toxicity of 120 ld50 of cadmium chloride cdcl2 on male albino rats by oral ingestion and to determine the hepatoprotective effect of solanum nigrum linn sn dried fruits and their ethanolic extract against cdcl2 toxicity using biochemical parameters. Hepatoprotective effect of a polyherbal extract containing andrographis paniculata, tinospora cordifolia and solanum nigrum against paracetamol induced hepatotoxicity dewasya pratap singh, 1 harshika awasthi, 1 suaib luqman, 2, 4 saudan singh, 3 and dayanandan mani 1, 4. Aqueous extract of solanum nigrum leaves aesn was prepared and subjected to various phytochemical screening. Sn is an herbal plant that has been used as hepatoprotective and antiinflammation agent in chinese medicine. Inhibitory effect of solanum nigrum on thioacetamide. Abu hossain abstract solanum nigrum is an important plant in traditional medicines belongs to the family of solanaceae. Hepatoprotective effects of solanum nigrum linn extract against ccl. Effect of dried fruits of solanum nigrum linn against ccl 4induced hepatic damage in rats. Information about the openaccess article screening of hepatoprotective effect of methanolic extract of solanum nigrum against paracetamol in doaj. Hepatoprotective effect of the total alkaloid fraction of solanum. Hepatoprotective effects of solanum nigrum linn extract. The fruit, root, leaves, flowers berry and the entire plant is used as medicine.
Subash kr, ramesh ks, binoy v 2011 study of hepatoprotective activity of solanum nigrum and cichorium intybus. Solanum nigrum medicinal uses and images nightshade makoi solanum nigrum also known as black nightshade or makoi h kakamachi is a perennial shrub found in wooded areas. Albino wistar rats weighing 150200g of either sex were divided into six groups of six animals each. Screening of hepatoprotective effect of methanolic extract of. Solanum nigrum in herbal medicine of india for ulcer therapy. So, the present study was undertaken to explore the hepatoprotective activity of s. Screening of hepatoprotective effect of methanolic extract.
The hepatoprotective mechanism of this herbal drug as well as active principles is not known. Among the medicinal plants, solanum nigrum family solanaceae known as black night shade, mako is a useful. Aromatic water extracted from the drug is widely prescribed by herbal vendors for liver disorders. In this study, the protective effects of water extract of sn sne against liver damage were evaluated in carbon tetrachloride ccl4. The larval mortality was below 60% when gram positive and six gram negative bacteria were used. The present work discusses the separation and purification of bioactive compounds from the crude ethanolic extracts of cassia italica and solanum nigrum leaves. Solanum nigrum medicinal uses and images nightshade. The fatty oil from the seeds of solanum nigrum linn. The water extracts showed a hepatoprotective effect against ccl4induced liver damage, which was evident by the decrease.
Hepatoprotective effects of solanum nigrum against ethanol. Accepted 27 june, 2011 the hepatoprotective effects of solanum nigrum water and methanolic extracts were studied in rats injected with 0. Effect of solanum nigrum linn against lambda cyhalothrin. Oral mucositis is one of the most debilitating side effects in patient undergoing chemotherapy or chemoradiotherapy. In this study, the protective effects of water extract of sn sne against liver damage were evaluated in carbon tetrachloride ccl 4induced chronic hepatotoxicity in rats. Aboulenein1, faten abu elela1, emad shalaby1 and hany elshemy1 abstract. The presence of plant extracts of solanum nigrum and cichorium intybus in the reaction mixture containing calf thymus dna and free radical generating. Solanum nigrum in ayurveda, the drug is known as kakamachi. Results indicated protein content of the leaves and seed as 24. Ethanol extract of solanum nigrum linn was investigated for its hepatoprotective activity against ccl 4induced hepatic damage in rats. Solanum nigrum, the european black nightshade or simply black nightshade or blackberry nightshade, is a species in the genus solanum, native to eurasia and introduced in the americas, australasia, and south africa.
Hepatoprotective effects of solanum nigrum against ethanolinduced injury in primary hepatocytes and mice with analysis of glutathione stransferase a1. Leaves of the plant solanum nigrum are used in folklore medicine to treat oral ulcers in india. Elhag ram, badwi mae 2011 hepatoprotective activity of solanum nigrum extracts on chemically induced liver damage in rats. The extract of solanum nigrum and cichorium intybus were administered to the. Hepatoprotective effects of solanum nigrum against ethanolinduced injury in primary hepatocytes and mice with analysis of glutathione stransferase a1 fangping liu a, xin ma a, minmin li a, zhi li a, qing han a, rui li a, changwen li b, yicong chang a, changwei zhao a, yuexia lin a.
Hepatoprotective effect of aqueous extract of solanum. Phytochemistry and pharmacological studies on solanum. The extract of solanum nigrum and cichorium intybus were administered to the experimental rats. Hepatoprotective effects of solanum nigrum linn fruits. Solanum nigrum sn is a shrub which is widely distributed throughout india. Protective effects of aqueous extract of solanum nigrum.
The activity was evaluated using biochemical parameters such as serum aspartate amino transferase ast, alanine amino transferase alt, alkaline phosphatase alp and total bilirubin. Effect of dried fruits of solanum nigrum l against ccl. Today, many authors speak of the solanum nigrum complex, which refers to all of the dozens of black nightshade species around the world formerly called s. Snl glycoprotein was isolated and tested for antioxidative effects oil oxygen free radicals using a 1,1diphenyl2picrylhydrazyl dpph assay. Comparative transcriptome analysis of cadmium responses in. Solanaceae commonly known as black nightshade that have been extensively used in traditional medicine in india and other parts of world to cure liver disorders, chronic. To our knowledge, of the genus solanum, the in vivo hepatoprotection by s. In this present investigation we used solanum nigrum for the antimicrobial activity and hepatoprotective activity against acetaminophen induced liver toxicity in male albino rats. The international status of ipgri is conferred under an.
The present study further investigated the healthprotective potential of genus solanum and therefore, evaluated the antioxidative, antiapototic and anti. Effect of dried fruits of solanum nigrum l inn against ccl. Traditionally the plant has been used for curing various ailments related to gastroenterology and hepatology. The important chemical groups present in the aqueous extract canbe. The results of this study indicated that the aqueous extract of s. In all of the tests, the extracts showed a potent antioxidant effect com. The water extracts showed a hepatoprotective effect against ccl. The present study was designed to demonstrate the antioxidant and hepatoprotective effect of solanum grandiflorum s. Hepatoprotective activity of solanum nigrum extracts on. Request pdf hepatoprotective effects of solanum nigrum linn extract against ccl solanum nigrum l.